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On the RV forums I visit, its commonly stated trailer tires have an expected life span of 3-5 years with 5 years being the maximum.

I tend to replace them about every 5-6 years but because I visibly see deterioration such as drying and even cracking which is waiting too long. My trailers sit outside in the Florida sun all the time and its a rough environment on tires. I've never had one fail on the road but I am pretty good about making sure they are properly inflated. Under inflation is the most common cause of tire failure supposedly.